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The compound provides been well tolerated at doses as high as 2000 mg/day with minimal toxicity and no dosage limiting toxicity offers been observed.. Abiraterone reduces degrees of prostate specific antigen For prostate cancer individuals whose tumors have continued to grow despite medical or surgical castration, a new drug candidate that inhibits creation of male hormones anywhere in the body is showing promise in early trials. Two poster presentations at the ESMO Conference Lugano this week show that the drug, called abiraterone, reduced degrees of prostate specific antigen , a marker of tumor activity, and shrank tumors in individuals in whom hormone therapy experienced stopped working and in addition in patients who had previously been treated with chemotherapy. Man hormones such as testosterone are stated in the testes mainly, but are produced by the adrenal gland and elsewhere in the body also.