Axel Hauschild.

An unbiased protection and data monitoring panel provided oversight and evaluated interim results on efficacy data. Data were gathered by the sponsor and analyzed in collaboration with the senior academic authors, who vouch for the completeness and precision of the data and analyses and for the conformance of the report to the protocol, as amended. The corresponding educational author prepared an initial draft of the manuscript in collaboration with the sponsor. All the authors contributed to subsequent drafts and made the decision to send the manuscript for publication.With raptor as the prime suspect, lead author and graduate student Dana Gwinn and various other members of the Shaw lab undertook extensive biochemical research to show that AMPK indeed straight phosphorylated raptor in response to energy stress, that mTOR activity then decreased, and that of most this kept starving cells from dividing until they dropped. The study provides stunning insight into Mother Nature’s reluctance to tinker with strategies that match organisms’ most elementary needs. Simply the most rudimentary info that any cell needs is to learn whether there is food around-that’s what AMPK senses. When there is not, you should turn off factors that produce cells grow, explains Shaw, to the growth-advertising team of raptor and mTOR specifically.